Searchable abstracts of presentations at key conferences in endocrinology

ea0099p19 | Adrenal and Cardiovascular Endocrinology | ECE2024

Intra-tissular profile of adrenal steroids reveals variable levels associated with adrenocortical tumors (ACT) differentiation and suggests alterations in steroids export

Bonnet-Serrano Fideline , Thomeret Louis , Benanteur Nesrine , Vaduva Patricia , Bouys Lucas , Ragazzon Bruno , Berthon Annabel , Perlemoine Karine , Zientek Corinne , Gaillard Martin , Violon Florian , Sibony Mathilde , Laguillier-Morizot Christelle , Menet Marie-Claude , Groussin Lionel , Guibourdenche Jean , Jouinot Anne , Assie Guillaume , Bertherat Jerome

Introduction: Adrenal steroidogenesis is alterated in adrenocortical tumors (ACT), leading frequently to abnormal steroid secretion. The development of steroid assays by mass spectrometry (MS) has greatly advanced the characterization of these alterations. However, steroid profiles are classically performed in blood and urine, providing a limited insight into adrenal steroidogenesis, altered by the mixing with gonadal steroids and by the steroid peripheral catabolism. The obje...

ea0099oc7.4 | Oral Communications 7: Endocrine-related Cancer | ECE2024

Single-nucleus atlas of adrenocortical carcinoma reveals tumor ecotypes associated with outcome

Assie Guillaume Jouinot Anne , Martin Yoann , Foulonneau Thomas , Bendjelal Yanis , Violon Florian , Calvet Philip , Izac Brigitte , Letourneur Franck , Bertholle Celine , Andrieu Muriel , Onifarasoaniaina Rachel , Favier Maryline , De Guitaut Charlene , Fraikin Archibald , De Murat Daniel , Armignacco Roberta , Benanteur Nesrine , Sibony Mathilde , Perlemoine Karine , Bonnet Fideline , Gaillard Martin , Dousset Bertrand , Pasmant Eric , Barat Maxime , Dohan Anthony , Haissaguerre Magalie , Tabarin Antoine , Libe Rossella , Guignat Laurence , Groussin Lionel , Berthon Annabel , Ragazzon Bruno , Bertherat Jerome , Assie Guillaume

Background: Bulk genomic studies have identified distinct molecular classes of adrenocortical tumors (ACT). Transcriptome profiles separate benign ACT (“C2” cluster) from carcinomas (ACC) and identify two groups of ACC, “C1A” (“steroid” and “proliferation” signatures) and “C1B” (“immune” signature), of poor and better prognosis respectively. However, these signatures were characterized at the tissue level (“bulk&...